Tumor List

Case Symptoms and Presentation
Ollier's syndrome

The child has abnormal growth, shortening, and deformity of the affected limb.

Enchondroma

Most patients have no symptoms. The most common presentation is a patient who has injured their knee or shoulder and who has an x-ray, leading to the discovery of the previously asymptomatic lesion. Lesions in the hands and the feet can weaken the bone and cause pain swelling and small pathological fractures during activities.

Enchondroma - Foot and Ankle

Patients present with pain during activities or after an injury, but there is rarely any mass palpable on physical examination. For enchondromas in the phalanges, pathological fracture through the lesion will cause the patient to seek medical care. A few patients have multiple enchondromas and warrant special attention and possibly referral to a bone tumor specialist.

Enchondroma

Most patients have no symptoms. The most common presentation is a patient who has injured their knee or shoulder and who has an x-ray, leading to the discovery of the previously asymptomatic lesion. Lesions in the hands and the feet can weaken the bone and cause pain swelling and small pathological fractures during activities.

Enchondroma - Foot and Ankle

Patients present with pain during activities or after an injury, but there is rarely any mass palpable on physical examination. For enchondromas in the phalanges, pathological fracture through the lesion will cause the patient to seek medical care. A few patients have multiple enchondromas and warrant special attention and possibly referral to a bone tumor specialist.

Paget's Disease

Paget's sarcoma usually presents as a new, progressive pain in a patient with long standing Paget's disease. Other symptoms can include soft tissue swelling or pathological fractures. The serum alkaline phosphatase which is elevated with Paget's disease may rise further with onset of sarcoma.

Eosinophilic Granuloma

EG is normally symptomatic. Local pain, swelling and tenderness are common and the ESR may be elevated.

Epithelioid Hemangioendothelioma

Clinically, epithelioid hemangioendotheliomas presents with pain and swelling. If present in the spine, a lesion may cause radicular symptoms or paraplegia.

Epithelioid Hemangioendothelioma

Clinically, epithelioid hemangioendotheliomas presents with pain and swelling. If present in the spine, a lesion may cause radicular symptoms or paraplegia.

Epithelioid Hemangioma

Clinically, patients usually present with pain over the involved sites.

Epithelioid Sarcoma

The tumor may present as a small, firm superficial or deep nodule or a focal cluster of nodules. Regional multifocal presentation is an unusual characteristic displayed by this tumor. This tumor is frequently misdiagnosed as a skin condition, warts, or corns, and a correct diagnosis may be delayed with serious medical and legal consequences. About one half of the tumors are not painful. The tumor occurs in both subcutis and deeper tissues. When located in the subcutis, it usually presents as a firm nodule that may be solitary or multiple, has a calluslike consistency, and is often described as a “woody hard knot” or :firm lump” that is slow growing and painless. Nodules situated in the dermis are often elevated above the skin surface and frequently become ulcerated weeks or months after they are first noted. Such lesions are often erroneously diagnosed as an “indurated ulcer”, “draining abscess”, or “infected wart” that fails to heal despite intensive therapy. The majority of tumors are 3 to 6 cm in diameter.

Lymph node metastasis should be evaluated at the time of presentation, due to the unusual propensity of this tumor to spread to regional nodes. In general, lymph node metastasis in sarcomas are quite rare, occurring in about 2.6% of all sarcoma patients in large series. In ES, however, the rate of lymph node metastasis is around 30% (range 14 - 44%) Lung metastasis occurs in 20-40% of patients.

Epithelioid sarcoma - Foot and Ankle

The tumor may present as a small, firm superficial or deep nodule or a focal cluster of nodules. Regional multifocal presentation is an unusual characteristic displayed by this tumor. This tumor is frequently misdiagnosed as a skin condition, warts, or corns, and a correct diagnosis may be delayed with serious medical and legal consequences. About one half of the tumors are not painful. The tumor occurs in both subcutis and deeper tissues. When located in the subcutis, it usually presents as a firm nodule that may be solitary or multiple, has a calluslike consistency, and is often described as a “woody hard knot” or :firm lump” that is slow growing and painless. Nodules situated in the dermis are often elevated above the skin surface and frequently become ulcerated weeks or months after they are first noted. Such lesions are often erroneously diagnosed as an “indurated ulcer”, “draining abscess”, or “infected wart” that fails to heal despite intensive therapy. The majority of tumors are 3 to 6 cm in diameter.

Erdheim–Chester disease (ECD)

Patients mostly present with pain in lower extremity. The involvement is usually bilateral and symmetrical. There is specific involvement of the appendicular skeletal, though involvement of the axial skeleton has also been reported. There can be associated general symptoms like fever, myalgia, weight loss, night sweats and flu like symptoms. The patient with systemic involvement can present with neurological symptoms, diabetes insipidus, exophthalmos, skin xanthomas and low back pain due to retroperitoneal fibrosis.

Ewing sarcoma - Foot and Ankle

Patients normally have pain accompanied by significant diffuse swelling. The area may appear inflamed and a misdiagnosis of infection can be made. The white blood cell count, erythrocyte sedimentation rate and temperature may all be moderately elevated.

Patients have symptoms for an average of 14 months prior to diagnosis. Patients with hindfoot lesions have an average duration of symptoms of 22 months prior to diagnosis, whereas those with forefoot lesions have an average duration of symptoms of seven months.

Ewing's Sarcoma

The clinical presentation of Ewing's sarcoma includes pain and swelling of weeks or months duration. Erythema and warmth of the local area are sometimes seen. Osteomyelitis is often the initial diagnosis based on intermittent fevers, leukocytosis, anemia and an increased ESR.

Extraskeletal Osteosarcoma
Extraskeletal Myxoid Chondrosarcoma

Approximately 80% of these tumors occur in the extremities, and 20% in the trunk. The lower extremity is the most common site. Patients present with swelling, and the tumor can be quite bulky.

Extraskeletal Osteosarcoma
Chondromyxoid Fibroma

The clinical presentation is usually chronic pain, swelling and possibly a palpable soft tissue mass or restriction of movement. Only 5% of patients with CMF present with a pathological fracture.

Desmoplastic Fibroma

Clinical findings include pain late in the clinical course and swelling. It may present as an effusion if near a joint. Only 12% present with a pathological fracture.