Tumor List

Clinically, hyperparathyroidism presents as "stones, bones and groans". The stones refers to recurrent kidney stones. Bones refers to the bone lesions that occur in severe or prolonged cases. Groans is meant to describe the gastrointestinal symptoms of nausea, vomiting, peptic ulcers and pancreatitis as well as the obtundation that occurs with hypercalcemia.

Usually pain is the presenting symptom in primary bone disease. Weight loss and malaise may be absent. Lytic lesions are most common, but mixed or sclerotic lesions can also be seen. Lesions may be associated with a periosteal reaction. Bone scintigraphy is useful in detection of skeletal HD. MRI is very sensitive in the localization of subtle marrow disease. Marrow involvement produces a hypointense signal on T1 weighted spin echo sequences and high signal on T2 weighted gradient echo sequences.

It may present as local pain or swelling. Patients generally feel they are in good health otherwise.

Most of these tumors are not symptomatic and are discovered as an incidental lesion. Some patients may present with pain, and pathological fracture can occur. Despite concern for pathologic fracture in lipoma of the calcaneus, the actual risk of fracture appears to be minimal or zero.

Most of these tumors are not symptomatic and are discovered as an incidental lesion. Some patients may present with pain, and pathological fracture can occur.

Most of these tumors are not symptomatic and are discovered as an incidental lesion. Some patients may present with pain, and pathological fracture can occur. Despite concern for pathologic fracture in lipoma of the calcaneus, the actual risk of fracture appears to be minimal or zero.

In the case presented, the lesion was very painful to the touch and the patient was unable to walk due to the pain.

The disease may be localized or widespread. Most patients present with pain. Other tumors may occur. The number of patients who develop sarcomas varies according to the reports. Patients with extensive lesions have a higher risk. About 15% develop chondrosarcoma, and one-third have other sarcomas, including vascular and fibrous sarcomas. The rate of chondrosarcoma is lower than see in Ollier disease. Other benign and malignant tumors may occur, including pituitary adenoma, glioma, uterine fibroids and polyps, mesenchymal ovarian tumors, adrenal cortical adenoma, fibrosarcoma, and carcinoma of the pancreas.

Clinically, MFH presents with local pain and swelling. There is often a history of a rapidly enlarging mass. Pathologic fractures are present 20% of the time. Radiologically, MFH is an aggressive, permeative lesion which often lacks distinctive features found in other high grade primary bone malignancies. It usually presents with a soft tissue mass with or without cortical erosion. There is not normally a periosteal reaction.

Clinical manifestations of bone metastasis from malignant melanoma are severe, sometimes intractable pain, and occasionally systemic manifestations such as fever.

Patients present with a soft tissue mass. Approximately two thirds of the masses are cutaneous, and one third are deep. The size of the mass depends on the delay in seeking treatment and location. Reported sizes range from 1 to 20 cm with a mean of approximately 5 cm. Males and females are equally affected. Patients ranged from age 3 to age 83, with a mean of 38.

Mutation of the GS gene in chromosome 20q13 occurs early in development, and results in a mosaic of abnormal and mutated cells. The manifestations of MAS in each individual depend upon the extent and distribution of abnormal cells. Abnormal and prolonged activation of multiple peripheral endocrine glands occurs even while the necessary stimulatory pituitary hormones may be absent. Precocious puberty, with onset of breast development, pubic hair, and the onset of menses as early as the first few months of life may occur in females. Other manifestations include acromegaly, hyperthyroidism, hyperprolactinemia, and others.

Frequently involved bones include the femur, the tibia, the facial skeleton, and the ribs. Bone fragility and associated fractures are common, and weight-bearing bones may suffer multiple fractures. In the proximal femurs, multiple successive cortical microfractures may result in characteristic bowing of the proximal end of the bone into a "shepherd's crook" deformity.

Clinical manifestations of bone metastasis from malignant melanoma are severe, sometimes intractable pain, and occasionally systemic manifestations such as fever.

Adults generally complain of pain, joint stiffness, and progressive deformity. In children the condition affects mainly the bones of the extremities and pelvis, and may result in limb length inequality, deformity, or joint contractures. Joint contractures may be accompanied by extraosseous bone formation.

Adults generally complain of pain, joint stiffness, and progressive deformity. In children the condition affects mainly the bones of the extremities and pelvis, and may result in limb length inequality, deformity, or joint contractures. Joint contractures may be accompanied by extraosseous bone formation.

Patients present with local pain and a mass. Headache occurs in the skull lesions. Base of skull lesions present with brainstem symptoms, and cranial nerve dysfunction.